Filters

GIT1(Ser375) Antibody

GIT1(Ser375) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGIT1(Ser375) Primary Polyclonal Antibody
Also known asGIT1(Ser375) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGIT1 Ser375
SpecificityThis is a highly specific antibody against GIT1 Ser375
Modification(s)Phosphorylation
Modification site(s)Ser375
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human GIT1 around the phosphorylation site of Ser375
Gene ID number28964
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3, thus reducing b2-adrenergic receptor signaling (5), which are involved in vesicular trafficking (5, 2), 4), 6), Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ARF GAP GIT1, ARF GTPase activating protein GIT1, CAT 1, Cat1, Cool associated and tyrosine phosphorylated protein 1, G protein coupled receptor kinase interactor 1, GRK interacting protein 1, p-GIT1 S375, GIT1 phospho S375
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGIT1(Ser375)
Short nameGIT1(Ser375) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGIT1(Ser375) (Antibody to)
Alternative techniqueantibodies
Identity 4272
Gene GIT1
Long gene name GIT ArfGAP 1
Synonyms gene name G protein-coupled receptor kinase interactor 1 G protein-coupled receptor kinase interacting ArfGAP 1
Locus 17q11, 2
Discovery year 2000-07-31
GenBank acession AF124490
Entrez gene record 28964
Pubmed identfication 9826657 10896954
RefSeq identity NM_014030
Classification Ankyrin repeat domain containing ArfGAPs
Havana BLAST/BLAT OTTHUMG00000132730

Similar products

Subscribe to our Newsletter