| Also known as | HIF1 alpha |
| Other names | ARNT interacting protein, ARNT-interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1-alpha, Hypoxia-inducible factor 1-alpha, Member of PAS protein 1, PAS domain-containing protein 8, PAS domain-containing protein 8, alpha subunit (basic helix-loop-helix transcription factor), alpha subunit (basic helix-loop-helix transcription factor), bHLHe78, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia inducible factor 1, hypoxia-inducible factor 1, hypoxia-inducible factor 1 alpha isoform I, hypoxia-inducible factor 1-alpha, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1, 3, hypoxia-inducible factor 1-alpha isoform 3 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | HIF1A |
| Gene name synonims | N/A |
| Other gene names | BHLHE78, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, HIF1-alpha, HIF1A, MOP1, MOP1, PASD8, PASD8, bHLHe78, bHLHe78, HIF1A |
| Clonality | Monoclonal |
| Immunoglobulin isotype | kappa, IgG2b |
| Clone | HIF1A-84 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | ARNT, B lymphocyte development and immune reactions, Besides their critical role in hypoxic response, Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions, HIF1s regulates the transcription of genes responsible for angiogenesis, Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, In normoxic cells, Sim) family, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a heterodimeric transcription factor complex central to cellular response to hypoxia, adipogenesis, carotid body formation, cell proliferation/survival, cobalt etc, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, contrastingly, erythropoiesis/iron-metabolism, glucose metabolism, growth factors, oncogenic activation, or loss of tumor suppressor function etc, ubiquitination and followed by rapid proteasomal degradation, whereas, ) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, HIF1 (hypoxia-inducible factor 1) |
| Purification method | N/A |
| Form/Appearance | N/A |
| Concentration | N/A |
| Storage and shipping | Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications: | Flow Cytometry (FC/FACS), Functional Studies, Immunofluorescence (IG), ELISA (EIA) |
| Gene target | HIF1 alpha |
| Short name | HIF1 alpha |
| Alternative name | HIF1 a |
| Identity | 4910 |
| Gene | HIF1A |
| Long gene name | hypoxia inducible factor 1 alpha subunit |
| Synonyms gene name | alpha subunit (basic helix-loop-helix transcription factor) , hypoxia inducible factor 1 |
| Synonyms | MOP1 HIF-1alpha PASD8 HIF1 bHLHe78 |
| Locus | 14q23, 2 |
| Discovery year | 1995-03-27 |
| GenBank acession | U22431 |
| Entrez gene record | 3091 |
| Pubmed identfication | 8786149 9079689 |
| RefSeq identity | NM_001530 |
| Classification | Basic helix-loop-helix proteins |
| Havana BLAST/BLAT | OTTHUMG00000140344 |
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