| Long name | INPPL1 Primary Polyclonal Antibody |
| Also known as | INPPL1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | INPPL1 |
| Specificity | This is a highly specific antibody against INPPL1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 715-765/1258 |
| Subcellular location | Cell membrane, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human INPPL1 |
| Gene ID number | 3636 |
| Swiss Prot | O15357 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation, Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A), Acts as a regulator of neuritogenesis by regulating PtdIns(3, Confers resistance to dietary obesity, Involved in EGF signaling pathway, May act by regulating AKT2, Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), Part of a signaling pathway that regulates actin cytoskeleton remodeling, Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3, Plays a central role in regulation of PI3K-dependent insulin signaling, Plays a negative role in regulating the PI3K-PKB pathway, Regulates cell adhesion and cell spreading, Required for HGF-mediated lamellipodium formation, Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, Upon stimulation by EGF, While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, although the precise molecular mechanisms and signaling pathways remain unclear, and later, but not AKT1, cell scattering and spreading, having a major impact on ligand-induced EGFR internalization and degradation, it is recruited by EGFR and dephosphorylates PtdIns(3, its absence does not affect insulin signaling or GLUT4 trafficking, maintain proper neurite outgrowth, phosphorylation at the plasma membrane, playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems, possibly by inhibiting PKB activity, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways, 4, 4, 4, 4, 4, 4)P2, 5)P3, 5)P3 level and is required to form an initial protrusive pattern, 5)P3 thereby regulating membrane ruffling, 5)P3) to produce PtdIns(3, 5-trisphosphate (PtdIns(3, Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, SH2 domain-containing inositol phosphatase 2, SHIP-2, SHIP2, 4, 5-trisphosphate 5-phosphatase 2, OPSMD |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | INPPL1 |
| Short name | INPPL1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | inositol polyphosphate phosphatase-like 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | INPPL1 and IDBG-63291 and ENSG00000165458 and 3636, INPPL1 and IDBG-635082 and ENSBTAG00000019167 and 783833, Inppl1 and IDBG-202184 and ENSMUSG00000032737 and 16332, OPSMD and SHIP2, Plasma membranes, SH2 domain binding, this GO :0001958 and endochondral ossification and biological process this GO :0002376 and immune system process and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006897 and endocytosis and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030175 and filopodium and cellular component this GO :0032868 and response to insulin and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0097178 and ruffle assembly and biological process, this GO :0003779: actin binding, this GO :0003779: actin binding and also this GO :0005515: protein binding and also this GO :0016787: hydrolase activity and also this GO :0017124: SH3 domain binding and also this GO :0042169: SH2 domain binding, this GO :0005515: protein binding, this GO :0016787: hydrolase activity, this GO :0017124: SH3 domain binding, this GO :0042169: SH2 domain binding, inositol polyphosphate phosphatase-like 1 |
| Identity | 6080 |
| Gene | INPPL1 |
| Long gene name | inositol polyphosphate phosphatase like 1 |
| Synonyms | SHIP2 |
| Synonyms name | 51C protein SH2 domain-containing inositol 5', -phosphatase 2 phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 2 |
| Locus | 11q13, 4 |
| Discovery year | 1995-05-12 |
| GenBank acession | Y14385 |
| Entrez gene record | 3636 |
| Pubmed identfication | 8530088 |
| RefSeq identity | NM_001567 |
| Classification | Phosphoinositide phosphatases Sterile alpha motif domain containing SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000167879 |
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