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Lefty Antibody

Lefty Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLefty Primary Polyclonal Antibody
Also known asLefty PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLefty
SpecificityThis is a highly specific antibody against Lefty
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Lefty
Gene ID number10637
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Cleavage is therefore an essential step for Lefty activation, Complexes formed move into the nucleus, Lefty, Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor, Lefty also inhibits events downstream from R Smad phosphorylation, Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms), Lefty provides a repressed state of TGF beta responsive genes, Members of the TGF beta superfamily require processing for their activation, Secreted growth factors of the TGF beta family, TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells, TGF beta actions are directed by ligand induced activation of TGF beta receptors, The 28kDa form induces MAPK activity, The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, a left right axis is established, a novel member of the TGF beta superfamily, and Lefty A and Lefty B in humans, including gene products derived from nodal, inhibits TGF beta signaling, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries, where they act as components of a transcriptional complex, During vertebrate embryogenesis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AI450052, Ebaf, FACTOR B, HOMOLOG OF antibody, LEFT-RIGHT DETERMINATION, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTB, LEFTY 1, LEFTY B, LEFTY1, LEFTY1, LEFTY1, LEFTYB, Left right determination factor 1, Left right determination factor B, Lefty, MOUSE, Protein lefty-B, RGD1561867, STRA3, Stimulated by retinoic acid gene 3 protein, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4, factor B, left right determination factor, left-right determination, left-right determination factor, lefty-1, Protein lefty-1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLefty
Short nameLefty Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLefty (Antibody to)
Alternative techniqueantibodies
Identity 11770
Gene TGFB4
Long gene name left-right determination factor 2
Synonyms gene EBAF
Synonyms gene name endometrial bleeding associated factor (left-right determination, factor A, transforming growth factor beta superfamily)
Synonyms LEFTA LEFTYA LEFTY2
Synonyms name LEFTY A) , beta-4 (endometrial bleeding-associated factor, transforming growth factor
Locus 1q42, 12
Discovery year 1998-01-20
GenBank acession U81523
Entrez gene record 7044
Pubmed identfication 9153275
RefSeq identity NM_003240
Havana BLAST/BLAT OTTHUMG00000037441

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