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MUSK Antibody

MUSK Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMUSK Primary Polyclonal Antibody
Also known asMUSK PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMUSK
SpecificityThis is a highly specific antibody against MUSK
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range260-310/869
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MUSK
Gene ID number4593
Swiss ProtO15146
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May also play a role within the central nervous system by mediating cholinergic responses, May positively regulate Rho family GTPases through FNTA, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, Mediates the phosphorylation of FNTA which promotes prenylation, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, synaptic plasticity and memory formation (By similarity), the kinase of the complex, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, the synapse between the motor neuron and the skeletal muscle (PubMed:25537362), Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FADS, MuSK, Muscle, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor, skeletal receptor tyrosine-protein kinase, CMS9
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMUSK
Short nameMUSK Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMUSK (Antibody to)
Alternative techniqueantibodies
Identity 7525
Gene MUSK
Long gene name muscle associated receptor tyrosine kinase
Synonyms gene name muscle, receptor tyrosine kinase , skeletal
Locus 9q31, 3
Discovery year 1997-04-10
GenBank acession AF006464
Entrez gene record 4593
Pubmed identfication 7546737
Classification I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000020485

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