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NLE1 Antibody

NLE1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNLE1 Primary Polyclonal Antibody
Also known asNLE1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNLE1
SpecificityThis is a highly specific antibody against NLE1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NLE1
Gene ID number54475
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, In plants, It may also play a role in 60S ribosomal subunit biogenesis in yeast, NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing, NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, NLE1 is crucial for normal cellular growth and development, Notch receptors play an important role in development and cell-fate decisions, Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1), Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation, regulating its signaling activity in Drosophila melanogaster and in mice, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway, The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names NLE 1, NLE1_HUMAN, Nle, Notchless gene homolog, Notchless homolog 1, Notchless homolog 1 Drosophila, Notchless protein homolog 1, FLJ10458
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNLE1
Short nameNLE1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNLE1 (Antibody to)
Alternative techniqueantibodies
Identity 19889
Gene NLE1
Long gene name notchless homolog 1
Synonyms gene name notchless homolog 1 (Drosophila)
Synonyms FLJ10458
Synonyms name (Drosophila) , Notchless gene homolog
Locus 17q12
Discovery year 2005-05-24
Entrez gene record 54475
RefSeq identity NM_018096
Classification WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000132928

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