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PANK2 Antibody

PANK2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePANK2 Primary Polyclonal Antibody
Also known asPANK2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPANK2
SpecificityThis is a highly specific antibody against PANK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PANK2
Gene ID number80025
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen All patients have the 'eye of the tiger' sign on brain MRI, Atypical forms have onset in the second decade, Classic forms present with onset in the first decade, Clinical manifestations include progressive muscle spasticity, HARP is a rare syndrome with many clinical similarities to NBIA1, Intermediate forms manifest onset in the first decade with slow progression or onset in the second decade with rapid progression, It is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain, It is clinically classified into classic, Patients with early onset tend to also develop pigmentary retinopathy, acanthocytosis, also known as pantothenate kinase-associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome (HSS), and intellectual deterioration which progresses to severe dementia over several years, and intermediate phenotypes, and pallidal degeneration (HARP), atypical, dysarthria, dystonia, hyperreflexia, loss of independent ambulation within 15 years, maintenance of independent ambulation up to 40 years later, muscle rigidity, primarily in the basal ganglia, rapid progression, retinitis pigmentosa, slow progression, whereas those with later onset tend to also have speech disorders and psychiatric features, Defects in PANK2 are the cause of hypoprebetalipoproteinemia, Defects in PANK2 are the cause of neurodegeneration with brain iron accumulation type 1 (NBIA1)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HARP, HSS, MGC15053, NBIA1, PANK2, PANK2_HUMAN, PKAN, Pantothenate kinase 2, Pantothenate kinase 2 Hallervorden Spatz syndrome, Pantothenic acid kinase 2, RP23 387C21, hPANK2, 4, C20orf48
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPANK2
Short namePANK2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePANK2 (Antibody to)
Alternative techniqueantibodies
Identity 15894
Gene PANK2
Long gene name pantothenate kinase 2
Synonyms gene C20orf48 NBIA1
Synonyms gene name neurodegeneration with brain iron accumulation 1 (Hallervorden-Spatz syndrome)
Synonyms HSS FLJ11729 PKAN HARP
Synonyms name Hallervorden-Spatz syndrome
Locus 20p13
Discovery year 2001-06-21
GenBank acession AK021791
Entrez gene record 80025
Pubmed identfication 8944032 11479594
RefSeq identity NM_024960
Havana BLAST/BLAT OTTHUMG00000031768
Locus Specific Databases LRG_1016

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