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PDK1(Ser241) Antibody

PDK1(Ser241) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePDK1(Ser241) Primary Polyclonal Antibody
Also known asPDK1(Ser241) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPDK1 Ser241
Specificity This phosphorylation site is homologous to Ser244 in Mouse and Rat, This is a highly specific antibody against PDK1 Ser241
Modification(s)Phosphorylation
Modification site(s)Ser241
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range220-260/556
Subcellular location Membrane bound, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241
Gene ID number5170
Swiss ProtO15530
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates PPARG transcriptional activity and promotes adipocyte differentiation, Activates the NF-kappa-B pathway via phosphorylation of IKKB, Controls proliferation, Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis, Its targets include: protein kinase B (PKB/AKT1, Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, PKB/AKT2, PKB/AKT3), Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells, Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response, Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses, RPS6KA2 and RPS6KA3), SGK2 and SGK3), SMAD3, SMAD4 and SMAD7, The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II, and growth of developing pancreatic cells, as well as glucose and amino acid uptake and storage, cyclic AMP-dependent protein kinase (PRKACA), p21-activated kinase-1 (PAK1), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, phosphorylating SMAD2, phosphorylating and activating a subgroup of the AGC family of protein kinases, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta, protein kinase C (PRKCD and PRKCZ), protein kinase PKN (PKN1 and PKN2), serum and glucocorticoid-inducible kinase (SGK1, survival, thus propagating the signal to downstream targets controlling cell proliferation and survival, Serine/threonine kinase which acts as a master kinase
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 3-phosphoinositide-dependent protein kinase 1, PDPK1, PDPK2, PDPK2P, PRO0461, hPDK1, PDK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPDK1(Ser241)
Short namePDK1(Ser241) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePDK1(Ser241) (Antibody to)
Alternative techniqueantibodies
Identity 8809
Gene PDK1
Long gene name pyruvate dehydrogenase kinase 1
Synonyms gene name isoenzyme 1 pyruvate dehydrogenase kinase, isozyme 1 , pyruvate dehydrogenase kinase
Locus 2q31, 1
Discovery year 1996-08-14
GenBank acession L42450
Entrez gene record 5163
Pubmed identfication 7499431
RefSeq identity NM_002610
Havana BLAST/BLAT OTTHUMG00000132285

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