Perforin Antibody

Perforin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	Perforin Primary Polyclonal Antibody
Also known as	Perforin PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	Perforin
Specificity	This is a highly specific antibody against Perforin
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Perforin
Gene ID number	5551
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	CTL granules containing perforin are exocytosed, During CTL-mediated cytotoxicity, IL-3, IL-4, IL-6 and to a lesser degree, It has been shown that abrogation of perforin function by Ca2+-complexing agents leads to decreased levels of necrosis, Perforin activity has been shown to be induced by IL-2, Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine proteases, Perforin is primarily expressed in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, TNF and IFN-Î, but has also been observed in an astrocyte population of the human brain, demonstrating that both necrosis and apoptosis contribute to CTL-mediated cytotoxicity, into target cells by forming transmembrane channels in target cell membranes, such as granzymes, which also plays a role in autoimmune diseases and transplant rejection, ³, The major defense of the body against virus-infected and tumorigenic cells is cytotoxic T lymphocyte (CTL)-mediated cytotoxicity
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	FLH2, HPLH2, Lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1, PERF_HUMAN, PFP, PGFL, PIGF, PIGF-2, PLGF, PRF 1, PRF1, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, Perforin-1, Pore forming protein, SHGC-10760, Cytolysin
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	Perforin
Short name	Perforin Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	Perforin (Antibody to)
Alternative technique	antibodies
Identity	9360
Gene	PRF1
Long gene name	perforin 1
Synonyms gene name	perforin 1 (pore forming protein)
Synonyms	PFP P1 HPLH2
Synonyms name	Perforin perforin 1 (preforming protein)
Locus	10q22, 1
Discovery year	1989-02-23
GenBank acession	BC047695
Entrez gene record	5551
Pubmed identfication	1505959 2592021
RefSeq identity	NM_005041
Classification	C2 domain containing
Havana BLAST/BLAT	OTTHUMG00000018412
Locus Specific Databases	PRF1base: Mutation registry for Familiar haemophagocytic lymphohistiocytosis, type II (FHL2) LRG_94

Perforin Antibody

Perforin Antibody size: 0.1ml 263

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