| Long name | Pin1 Primary Polyclonal Antibody |
| Also known as | Pin1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | Pin1 |
| Specificity | This is a highly specific antibody against Pin1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Pin1 |
| Gene ID number | 5300 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding, Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau, Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration, Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain, Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease, Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds, Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation, Pin1 is a Peptidyl-prolyl isomerases (PPIase) |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | NIMA interacting 1, PIN1_HUMAN, PPIase Pin1, Peptidyl prolyl cis trans isomerase NIMA interacting 1, Peptidyl prolyl cis/trans isomerase NIMA interacting, Pin 1, Prolyl isomerase, Protein NIMA interacting 1, Protein peptidylprolyl cis/trans isomerase NIMA interacting 1, Rotamase Pin1, UBL 5, UBL5, DOD |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | Pin1 |
| Short name | Pin1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | NIMA-interacting 1 (Antibody to), peptidylprolyl cis/trans isomerase |
| Alternative technique | antibodies |
| Identity | 8988 |
| Gene | PIN1 |
| Long gene name | NIMA-interacting 1 , peptidylprolyl cis/trans isomerase |
| Synonyms gene name | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 |
| Synonyms | dod |
| Locus | 19p13 |
| Discovery year | 1996-12-16 |
| Entrez gene record | 5300 |
| Pubmed identfication | 8606777 |
| Classification | Parvulins |
| Havana BLAST/BLAT | OTTHUMG00000180388 |
| Locus Specific Databases | LRG_847 |
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