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PRKAR1 Antibody

PRKAR1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePRKAR1 Primary Polyclonal Antibody
Also known asPRKAR1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPRKAR1
SpecificityThis is a highly specific antibody against PRKAR1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Protein Kinase A regulatory subunit I alpha
Gene ID number5573
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40), Four different regulatory subunits and three catalytic subunits have been identified in humans, Jul 2008], Mutations in this gene cause Carney complex (CNC), The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits, This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2, This gene encodes one of the regulatory subunits, This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids, Three alternatively spliced transcript variants encoding the same protein have been observed, [provided by RefSeq, cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits, cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins, cAMP is a signaling molecule important for a variety of cellular functions
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CAR, CNC, CNC 1, CNC1, DKFZp779L0468, KAP0_HUMAN, MGC17251, PKA RIA, PKR 1, PKR1, PPNAD 1, PPNAD1, PRKAR 1, PRKAR1, PRKAR1A, Protein kinase A type 1a regulatory subunitv Protein kinase cAMP dependent regulatory type I alpha, TSE 1, TSE1, Tissue specic extinguisher 1, cAMP dependent protein kinase regulatory subunit RIalpha, cAMP dependent protein kinase regulatory subunit alpha 1, cAMP dependent protein kinase type I alpha regulatory chain, cAMP dependent protein kinase type I alpha regulatory subunit, Protein Kinase A regulatory subunit I alpha
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPRKAR1
Short namePRKAR1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePRKAR1 (Antibody to)
Alternative techniqueantibodies
Identity 9388
Gene PRKAR1A
Long gene name protein kinase cAMP-dependent type I regulatory subunit alpha
Synonyms gene PRKAR1 TSE1
Synonyms gene name alpha protein kinase, cAMP-dependent, cAMP-dependent, regulatory, regulatory subunit type I alpha , tissue specific extinguisher 1 protein kinase, type I
Synonyms CNC1
Synonyms name Carney complex type 1
Locus 17q24, 2
Discovery year 1988-05-11
Entrez gene record 5573
Pubmed identfication 3479018 10973256
Havana BLAST/BLAT OTTHUMG00000180128
Locus Specific Databases LRG_514

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