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RANK Antibody

RANK Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRANK Primary Polyclonal Antibody
Also known asRANK PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRANK
SpecificityThis is a highly specific antibody against RANK
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RANK
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen CD265 is also expressed in dendritic cells, CD265 is widely expressed, Human and murine CD265 share 81% amino acid identity in their extracellular domains, Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265, RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells, RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis, TRANCE (TNF-related activation-induced cytokines, The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity, The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, The soluble form of CD265 is able to block TRANCE induced biological activity, also known as RANK ligand, colon, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis, liver, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265, small intestine and adrenal gland, thymus, with highest levels in skeletal muscle, CD265 is a member of the tumor necrosis factor receptor (TNFR) family
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Activator of NFKB, CD 265, CD265, CD265 antigen, EOF, FEO, NFKB activator, ODFR, OFE, Osteoclast dferentiation factor receptor, PDB 2, RANK receptor, Receptor activator of NF KB, TNFRSF 11A, TNFSF11, TNR11_HUMAN, TRANCE R, mRANK, receptor activator of nuclear factor kappa B, TNFRSF11A
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRANK
Short nameRANK Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRANK (Antibody to)
Alternative techniqueantibodies
Identity 11908
Gene TNFRSF11A
Long gene name TNF receptor superfamily member 11a
Synonyms gene PDB2 LOH18CR1
Synonyms gene name 18, NFKB activator , activator of NFKB Paget disease of bone 2 loss of heterozygosity, chromosomal region 1 tumor necrosis factor receptor superfamily, member 11a, member 11a, tumor necrosis factor receptor superfamily
Synonyms RANK CD265 FEO
Locus 18q21, 33
Discovery year 1998-12-04
GenBank acession AF018253
Entrez gene record 8792
Pubmed identfication 9367155 10615125
Classification CD molecules Tumor necrosis factor receptor superfamily
Havana BLAST/BLAT OTTHUMG00000132779
Locus Specific Databases LRG_194

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