| Long name | ROCK2 Primary Polyclonal Antibody |
| Also known as | ROCK2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ROCK2 |
| Specificity | This is a highly specific antibody against ROCK2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 1035-1085/1388 |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ROCK2 |
| Gene ID number | 9475 |
| Swiss Prot | O75116 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation, BRCA2, CNN1, DPYSL2, EP3, EZR, Inhibits keratinocyte terminal differentiation, Involved in regulation of smooth muscle contraction, MSN, MYL9/MLC2, May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles, NPM1, PPP1R12A and VIM, Phosphorylates SORL1 and IRF4, Plays a critical role in the regulation of spine and synaptic properties in the hippocampus, Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation, Plays an important role in the timely initiation of centrosome duplication, Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation, RDX, actin cytoskeleton organization, cell adhesion and motility via phosphorylation of ADD1, neurite retraction, stress fiber and focal adhesion formation, Protein kinase which is a key regulator of actin cytoskeleton and cell polarity |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | KIAA619, ROCK2, Rho kinase 2, Rho-associated, Rho-associated, Rho-associated protein kinase 2, coiled-coil-containing protein kinase 2, coiled-coil-containing protein kinase II, p164 ROCK-2, ROCK-II |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ROCK2 |
| Short name | ROCK2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | coiled-coil containing protein kinase 2 (Antibody to), Rho-associated |
| Alternative technique | antibodies |
| Alternative to gene target | ROCK-II, ROCK2 and IDBG-29657 and ENSG00000134318 and 9475, ROCK2 and IDBG-638012 and ENSBTAG00000005847 and 282041, Rock2 and IDBG-129486 and ENSMUSG00000020580 and 19878, coiled-coil containing protein kinase 2, nuclei, this GO :0000166 and nucleotide binding and molecular function this GO :0000910 and cytokinesis and biological process this GO :0001843 and neural tube closure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006939 and smooth muscle contraction and biological process this GO :0007411 and axon guidance and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0010825 and positive regulation of centrosome duplication and biological process this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0016772 and transferase activity, this GO :0000166: nucleotide binding, this GO :0000166: nucleotide binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005198: structural molecule activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005198: structural molecule activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0017048: Rho GTPase binding, this GO :0044822: poly(A) RNA binding, this GO :0046872: metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017048: Rho GTPase binding and also this GO :0044822: poly(A) RNA binding and also this GO :0046872: metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0017048 and Rho GTPase binding and molecular function this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0031616 and spindle pole centrosome and cellular component this GO :0032956 and regulation of actin cytoskeleton organization and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0036464 and cytoplasmic ribonucleoprotein granule and cellular component this GO :0042752 and regulation of circadian rhythm and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045616 and regulation of keratinocyte differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048511 and rhythmic process and biological process this GO :0051298 and centrosome duplication and biological process this GO :0051492 and regulation of stress fiber assembly and biological process this GO :0051893 and regulation of focal adhesion assembly and biological process this GO :2000114 and regulation of establishment of cell polarity and biological process this GO :2000145 and regulation of cell motility and biological process, Rho-associated |
| Identity | 10252 |
| Gene | ROCK2 |
| Long gene name | Rho associated coiled-coil containing protein kinase 2 |
| Locus | 2p25, 1 |
| Discovery year | 1999-04-23 |
| GenBank acession | D87931 |
| Entrez gene record | 9475 |
| Pubmed identfication | 9933571 |
| Classification | Pleckstrin homology domain containing |
| Havana BLAST/BLAT | OTTHUMG00000149916 |
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