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RPH3AL Antibody

RPH3AL Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRPH3AL Primary Polyclonal Antibody
Also known asRPH3AL PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRPH3AL
SpecificityThis is a highly specific antibody against RPH3AL
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RPH3AL
Gene ID number9501
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells, Rabphilin-3AL is expressed in a variety of tissues, Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells, Through an interaction with Rab 3, Via its RBD domain, With lower affinity, also known as RPH3AL or NOC2, but unlike its related protein, heart and thyroid, is a cytoplasmic Rab GTPase effector, liver, ovary, pancreas, rabphilin-3A, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion, rabphilin-3AL does not contain any C2 domains, rabphilin-3AL is capable of binding Rab 27a and, rabphilin-3AL is recruited to dense-core vesicles, skeletal muscle, stomach, through this interaction, with highest levels found in kidney, Rabphilin-3AL (rabphilin-3A-like)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Gm1753, No C2 domains protein, RPH3AL, RPH3L_HUMAN, Rab effector Noc2, Rabphilin 3A-like, Rabphilin 3A-like without C2 domains, Rabphilin-3A-like protein, Noc2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRPH3AL
Short nameRPH3AL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namerabphilin 3A-like (without complement component 2 domains) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, NOC2, RPH3AL and IDBG-13853 and ENSG00000181031 and 9501, RPH3AL and IDBG-632666 and ENSBTAG00000039819 and 617294, Rph3al and IDBG-200631 and ENSMUSG00000020847 and 380714, metal ion binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006887 and exocytosis and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0017137 and Rab GTPase binding and molecular function this GO :0017158 and regulation of calcium ion-dependent exocytosis and biological process this GO :0030141 and secretory granule and cellular component this GO :0030274 and LIM domain binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030667 and secretory granule membrane and cellular component this GO :0042493 and response to drug and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0045744 and negative regulation of G-protein coupled receptor protein signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050714 and positive regulation of protein secretion and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0008092: cytoskeletal protein binding and also this GO :0017137: Rab GTPase binding and also this GO :0030274: LIM domain binding and also this GO :0046872: metal ion binding, this GO :0008092: cytoskeletal protein binding, this GO :0017137: Rab GTPase binding, this GO :0030274: LIM domain binding, this GO :0046872: metal ion binding, rabphilin 3A-like (without C2 domains)
Identity 10296
Gene RPH3AL
Long gene name rabphilin 3A-like (without C2 domains)
Synonyms Noc2
Locus 17p13, 3
Discovery year 1999-04-14
Entrez gene record 9501
Pubmed identfication 10395805
RefSeq identity NM_006987
Havana BLAST/BLAT OTTHUMG00000090273

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