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SHARPIN Antibody

SHARPIN Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSHARPIN Primary Polyclonal Antibody
Also known asSHARPIN PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSHARPIN
SpecificityThis is a highly specific antibody against SHARPIN
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range260-310/387
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHARPIN
Gene ID number81858
Swiss ProtQ9H0F6
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways, LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex, Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation, Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis, Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PSEC0216, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, Sharpin, hSIPL1, SIPL1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSHARPIN
Short nameSHARPIN Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSHARPIN (Antibody to)
Alternative techniqueantibodies
Identity 25321
Gene SHARPIN
Long gene name SHANK associated RH domain interactor
Synonyms DKFZP434N1923 SIPL1
Locus 8q24, 3
Discovery year 2005-08-09
GenBank acession AL136816
Entrez gene record 81858
Pubmed identfication 11178875 12753155
RefSeq identity NM_030974
Classification Zinc fingers RANBP2-type Linear ubiquitin chain assembly complex
Havana BLAST/BLAT OTTHUMG00000165243

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