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SPG3A/Atlastin Antibody

SPG3A/Atlastin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSPG3A/Atlastin Primary Polyclonal Antibody
Also known asSPG3A/Atlastin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSPG3A/Atlastin
SpecificityThis is a highly specific antibody against SPG3A/Atlastin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SPG3A/Atlastin
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness, Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration, Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, Spastin, The Atlastin proteins, This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development, a microtubule (MT)-severing AAA ATPase, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance, integral membrane proteins that function as GTPases, is a binding partner of Atlastin that is involved in membrane dynamics, while mutations in the Spastin gene (SPG4) account for almost 40%, Atlastins are Golgi-localized
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ATLA1_HUMAN, Atlastin GTPase 1, Atlastin-1, Atlastin1, Brain specic GTP binding protein, Brain-specic GTP-binding protein, FSP1, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Guanylate binding protein 3, HSN1D, SPG 3A, SPG3, SPG3A, Spastic paraplegia 3 protein A, atl1, hGBP3, AD FSP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSPG3A/Atlastin
Short nameSPG3A/Atlastin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSPG3A/Atlastin (Antibody to)
Alternative techniqueantibodies
Identity 11231
Gene ATL1
Long gene name atlastin GTPase 1
Synonyms gene SPG3 SPG3A
Synonyms gene name spastic paraplegia 3A (autosomal dominant)
Synonyms FSP1 AD-FSP
Synonyms name atlastin
Locus 14q22, 1
Discovery year 1993-10-28
GenBank acession AF131801
Entrez gene record 51062
Pubmed identfication 8252041 7825576
Havana BLAST/BLAT OTTHUMG00000140297
Locus Specific Databases LRG_360

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