| Long name | STAT3 Primary Polyclonal Antibody |
| Also known as | STAT3 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | STAT3 |
| Specificity | This is a highly specific antibody against STAT3 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 260-310/770 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human STAT3 |
| Gene ID number | 6774 |
| Swiss Prot | P40763 |
| Tested Applications | FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions | FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Pig, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Activated by IL31 through IL31RA, Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes, Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity, FGFR2, FGFR3 and FGFR4, KITLG/SCF and other growth factors, May mediate cellular responses to activated FGFR1, Plays an important role in host defense in methicillin-resistant S, Signal transducer and transcription activator that mediates cellular responses to interleukins, aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ADMIO, Acute-phase response factor, HIES, STAT3, Signal transducer and activator of transcription 3, APRF |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | STAT3 |
| Short name | STAT3 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | signal transducer and activator on transcription 3 (acute-phase response factor) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ADMIO and APRF and HIES, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006606 and protein import into nucleus and biological process this GO :0006928 and cellular component movement and biological process this GO :0006953 and acute-phase response and biological process this GO :0007165 and signal transduction and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010033 and response to organic substance and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016032 and viral process and biological process this GO :0016310 and phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019827 and stem cell maintenance and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0019953 and sexual reproduction and biological process this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0031730 and CCR5 chemokine receptor binding and molecular function this GO :0032355 and response to estradiol and biological process this GO :0032870 and cellular response to hormone stimulus and biological process this GO :0034097 and response to cytokine and biological process this GO :0035259 and glucocorticoid receptor binding and molecular function this GO :0040014 and regulation of multicellular organism growth and biological process this GO :0042493 and response to drug and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0042755 and eating behavior and biological process this GO :0043434 and response to peptide hormone and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045471 and response to ethanol and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048708 and astrocyte differentiation and biological process this GO :0060019 and radial glial cell differentiation and biological process this GO :0060396 and growth hormone receptor signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0060548 and negative regulation of cell death and biological process this GO :0070102 and interleukin-6-mediated signaling pathway and biological process this GO :2001223 and negative regulation of neuron migration and biological process, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, nuclei, protein dimerization activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001659 and temperature homeostasis and biological process this GO :0001754 and eye photoreceptor cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0001103: RNA polymerase II repressing transcription factor binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0004871: signal transducer activity and also this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0019901: protein kinase binding and also this GO :0019903: protein phosphatase binding and also this GO :0031730: CCR5 chemokine receptor binding and also this GO :0035259: glucocorticoid receptor binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0046983: protein dimerization activity, this GO :0001103: RNA polymerase II repressing transcription factor binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0004871: signal transducer activity, this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0019901: protein kinase binding, this GO :0019903: protein phosphatase binding, this GO :0031730: CCR5 chemokine receptor binding, this GO :0035259: glucocorticoid receptor binding, this GO :0043565: sequence-specific DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0046983: protein dimerization activity, 508541, signal transducer and activator of transcription 3 (acute-phase response factor) |
| Identity | 11364 |
| Gene | STAT3 |
| Long gene name | signal transducer and activator of transcription 3 |
| Synonyms gene name | signal transducer and activator of transcription 3 (acute-phase response factor) |
| Synonyms | APRF |
| Locus | 17q21, 2 |
| Discovery year | 1995-11-08 |
| GenBank acession | BC014482 |
| Entrez gene record | 6774 |
| Pubmed identfication | 7512451 |
| RefSeq identity | NM_139276 NM_003150 |
| Classification | SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000150645 |
| Locus Specific Databases | STAT3base: Mutation registry for Hyper-IgE syndrome LRG_112 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue