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SUFU/Suppressor of Fused Antibody, Cy3 Conjugated

SUFU/Suppressor of Fused Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, SUFU/Suppressor of Fused Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenSUFU/Suppressor of Fused
SpecificityThis is a highly specific antibody against SUFU/Suppressor of Fused
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range440-484/484
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human SUFU
Gene ID number51684
Swiss ProtQ9UMX1
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Down-regulates GLI1-mediated transactivation of target genes, GLI2 and GLI3 in the cytoplasm, GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state, May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome, Negative regulator of beta-catenin signaling, Part of a corepressor complex that acts on DNA-bound GLI1, Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL), Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity), SUFU dissociates from GLI3FL and the latter translocates to the nucleus, Sequesters GLI1, When Hh signaling is initiated, Without the Hh signal, and converted to a transcriptional activator (GLI3A), destabilized, leading to the efficient processing of GLI3FL into GLI3R, the SUFU-GLI3 complex is recruited to cilia, this effect is overcome by binding of STK36 to both SUFU and a GLI protein, where it is phosphorylated, Negative regulator in the hedgehog signaling pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms SUFUH SUFUXL PRO1280
Properties 1 of the SUFU/Suppressor of Fused Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Description HRAS like - suppressor protein make genetic suppression restoring the phenotype seen prior to the original background in , breast cancer tumor, Kinase, biological pathways
Gene targetSUFU/Suppressor of Fused Conjugated
Short name Conjugated, SUFU/Suppressor of Fused Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, SUFU/Suppressor on Fused (Antibody to)
Alternative techniqueantibodies
Identity 16466
Gene SUFU
Long gene name SUFU negative regulator of hedgehog signaling
Synonyms gene name suppressor of fused homolog (Drosophila)
Locus 10q24, 32
Discovery year 2001-08-28
GenBank acession AF175770
Entrez gene record 51684
Pubmed identfication 15367681
RefSeq identity NM_016169
Havana BLAST/BLAT OTTHUMG00000018966
Locus Specific Databases LRG_521

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