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TLE4 Antibody

TLE4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTLE4 Primary Polyclonal Antibody
Also known asTLE4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTLE4
SpecificityThis is a highly specific antibody against TLE4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TLE4
Gene ID number7091
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Expression of the TLE genes, Groucho is a transcriptional repressor that plays a key role in neurogenesis, In early stages of cell differentiation, In later stages, Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, TLE1, TLE1, TLE1 and TLE4 contain SP and WD40 domains, TLE1 is upregulated, TLE2, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, TLE2 and TLE4 are upregulated, TLE3 and TLE4, TLEs associate with chromatin in live cells and specifically with Histone H3, also designated ESG for enhancer of split groucho), and TLE2 and TLE4 are downregulated, and expression of TLE1 decreases, but not with other core histones, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, particularly in the caudate nucleus, segmentation and sex determination, suggesting a role during epithelial differentiation, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor, which are human homologs of the Drosophila groucho gene, while TLE4 is most highly expressed in the brain, The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names B lymphocyte gene 1, ESG4, ESG4, KIAA1261, TIM, TIM1, TLE4, TLE4_HUMAN, enhancer of split groucho 4, enhancer of split groucho 4, timeless Drosophila homolog, transducin-like enhancer of split 4, transducin-like enhancer of split 4, B lymphocyte gene 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTLE4
Short nameTLE4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTLE4 (Antibody to)
Alternative techniqueantibodies
Identity 11840
Gene TLE4
Long gene name transducin like enhancer of split 4
Synonyms gene name Drosophila) , transducin-like enhancer of split 4 (E(sp1) homolog
Synonyms E(spI) ESG GRG4
Locus 9q21, 31
Discovery year 1993-12-20
GenBank acession M99439
Entrez gene record 7091
Pubmed identfication 8365415
RefSeq identity XM_212237
Classification WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000020072

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