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beta-Arrestin 1(Ser412) Antibody, ALEXA FLUOR 488

beta-Arrestin 1(Ser412) Antibody, ALEXA FLUOR 488 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, beta-Arrestin 1(Ser412) Antibody
Also known asAnti-beta-Arrestin 1Ser412 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target Antigenbeta-Arrestin 1Ser412
SpecificityThis is a highly specific antibody against beta-Arrestin 1Ser412
ModificationPhosphorylation
Modification SiteSer412
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
Gene ID Number408
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen After binding to their ligand and interacting with heterotrimeric G proteins, Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs, Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane, ERK1 and 2 signaling pathway, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues, It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, Raf, Serine 412 is then dephosphorylated and the GPCRs are internalized, Serving as an adaptor or scaffold molecule, beta 2 adrenergic receptor), beta Arrestin 1 is essential for mitogenic signaling, e, leading to activation of the Ras, Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system, g
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms ARB 1, ARB1, ARR 1, ARR1, ARRB 1, ARRB1, Arrestin beta 1, p-beta Arrestin 1 phospho S412, beta Arrestin 1 phospho S412
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the beta-Arrestin 1(Ser412) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetbeta-Arrestin 1(Ser412)
Short namebeta-Arrestin 1(Ser412) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, b-Arrestin 1(Ser412) (Antibody to)
Alternative techniqueantibodies

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