Filters

Epac1 Antibody

Epac1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEpac1 Primary Polyclonal Antibody
Also known asEpac1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEpac1
SpecificityThis is a highly specific antibody against Epac1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Epac1
Gene ID number1019
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, EPAC1 mRNA is broadly expressed, EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity, Egl-10 and pleckstrin homology domain) targeting the membrane anchors, Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex, Epac1 and Epac 2, The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains, The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade, The to Epac 1are affinity purified over immobilized antigen based chromatography, There are 2 members of the Epac family, kidney and certain brain regions, ovary, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands, with particularly high levels occurring in the thyroid, The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CAMP GEFI, CAMPGEFI, CGEF 1, CGEF1, EPA1, EPAC, EPAC1, Epac 1, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, MGC21410, RAP guanine nucleotide exchange factor, RAP guanine nucleotide exchange factor 3, RAPGEF3, Rap guanine nucleotide exchange factor GEF 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, cAMP regulated guanine nucleotide exchange factor I, bcm910
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetEpac1
Short nameEpac1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEpac1 (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter