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FGFR4

FGFR4 size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenFGFR4
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the FGFR4 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis FGFR4 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P22455
PurityAntigen affinity
Description Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR4 signaling is down-regulated by receptor internalization and degradation, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling, PIK3R1 and SOS1, Phosphorylates PLCG1 and FRS2, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, Required for normal down-regulation of the expression of CYP7A1, and in regulation of lipid metabolism, and mediates activation of RAS, as well as of the AKT1 signaling pathway, bile acid biosynthesis, differentiation and migration, glucose uptake, in response to FGF19, the rate-limiting enzyme in bile acid synthesis, vitamin D metabolism and phosphate homeostasis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation
ImmunogenThis FGFR4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 143-178 amino acids from the N-terminal region of human FGFR4
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FGFR4 antibody and store frozen at -20 deg
Gene targetFGFR4
Short nameFGFR4
Alternative nameFGFR4
Identity 3691
Gene FGFR4
Long gene name fibroblast growth factor receptor 4
Synonyms JTK2 CD334
Locus 5q35, 2
Discovery year 1991-07-25
GenBank acession AF202063
Entrez gene record 2264
Classification I-set domain containing CD molecules Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000151523

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