Girdin Antibody

Girdin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	Girdin Primary Polyclonal Antibody
Also known as	Girdin PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	Girdin
Specificity	This is a highly specific antibody against Girdin
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	1450-1500/1870
Subcellular location	Cell membrane, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APE/Girdin
Gene ID number	328
Swiss Prot	P27695
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Also involved in the DNA cleavage step of class switch recombination (CSR), Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, On the other hand, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, and single-stranded RNA molecules, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, single-stranded DNA regions of R-loop structures, such as the FOS/JUN AP-1 complex after exposure to IR, Multifunctional protein that plays a central role in the cellular response to oxidative stress
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	AP endonuclease 1, APE-1, APE1, APEN, APEX, APEX nuclease, APEX1, APX, Apurinic-apyrimidinic endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, HAP1, REF-1, REF1, Redox factor-1, APE
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	Girdin
Short name	Girdin Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	Girdin (Antibody to)
Alternative technique	antibodies
Identity	25523
Gene	CCDC88A
Long gene name	coiled-coil domain containing 88A
Synonyms gene	KIAA1212
Synonyms gene name	KIAA1212
Synonyms	FLJ10392 APE GIV HkRP1 GRDN
Synonyms name	Galpha-interacting vesicle-associated protein Akt-phosphorylation enhancer girdin girders of actin filaments
Locus	2p16, 1
Discovery year	2004-01-13
GenBank acession	AB033038 AF112218
Entrez gene record	55704
Pubmed identfication	15749703 15753085
RefSeq identity	NM_017571
Havana BLAST/BLAT	OTTHUMG00000151915

Girdin Antibody

Girdin Antibody size: 0.1ml 263

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