Filters

HCA57 Antibody

HCA57 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHCA57 Primary Polyclonal Antibody
Also known asHCA57 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHCA57
SpecificityThis is a highly specific antibody against HCA57
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TID1/HCA57
Gene ID number9093
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen A J domain mutant of hTid1L can dominantly suppress apoptosis and in sharp contrast the J domain mutant of hTid1S increases apoptosis, Expression of hTid1L increases apoptosis induced by DNA damaging agents as mitomycin C and TNF alpha, Expression of hTid1S and hTid1L affects cytochrome c release from the mitochondria and caspase 3 activation, Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals, It is strongly suggested that these two splice variants exert their anti and pro apoptotic effects through discrete substrates and activities, These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70, They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity, while activation of caspase 8 is unaffected, TID1 is a human homolog of the Drosophila tumor suppressor lethal tumerous imaginal discs and encodes two mitochondrial matrix localized splice variants of human Tid1 designated hTid1S and hTid1L
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DNJA3_HUMAN, DnaJ homolog subfamily A member 3 mitochondrial precursor, DnaJ protein Tid 1, DnaJ protein Tid1, HCA57, Hepatocellular carcinoma associated antigen 57, Highly similar to HYPOTHETICAL 105, III [Caenorhabditis elegans], TID1, Tumorous imaginal discs Drosophila homolog, Tumorous imaginal discs protein Tid56 homolog, hTid 1, hTid1, 5 IN CHROMOSOME, 9 KD PROTEIN F22B7, DnaJ Hsp40 homolog subfamily A member 3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHCA57
Short nameHCA57 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHCA57 (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter