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HER3(Tyr1328) Antibody

HER3(Tyr1328) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameHER3(Tyr1328) Primary Polyclonal Antibody
Also known asHER3(Tyr1328) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenHER3 Tyr1328
SpecificityThis is a highly specific antibody against HER3 Tyr1328
Modification(s)Phosphorylation
Modification site(s)Tyr1328
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1305-1342/1342
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1328 [PD(p-Y)WH]
Gene ID number2065
Swiss ProtP21860
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2), ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, Isoform 2 lacks the intermembrane region and is secreted outside the cell, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord, This form acts to modulate the activity of the membrane-bound form, also called Israeli Bedouin multiple contracture syndrome type A, bladder and breast tumors, ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ERBB3, ErbB-3, LCCS2, MDA-BF-1, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, HER3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetHER3(Tyr1328)
Short nameHER3(Tyr1328) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameHER3(Tyr1328) (Antibody to)
Alternative techniqueantibodies
Identity 3431
Gene ERBB3
Long gene name erb-b2 receptor tyrosine kinase 3
Synonyms gene LCCS2
Synonyms gene name lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms HER3
Synonyms name human epidermal growth factor receptor 3
Locus 12q13, 2
Discovery year 1990-07-15
GenBank acession M34309
Entrez gene record 2065
RefSeq identity NM_001982
Classification Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000170140
Locus Specific Databases LRG_996

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