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LIS1 Antibody

LIS1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLIS1 Primary Polyclonal Antibody
Also known asLIS1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLIS1
SpecificityThis is a highly specific antibody against LIS1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LIS1
Gene ID number5048
Swiss ProtP43034
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules, May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing, May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end, Neuronal migration involves a process called nucleokinesis, Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity), Positively regulates the activity of the minus-end directed microtubule motor protein dynein, Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate, Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates, Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names LIS-1, LIS1, LIS2, Lissencephaly-1 protein, MDCR, PAF acetylhydrolase 45 kDa subunit, PAF-AH 45 kDa subunit, PAF-AH alpha, PAFAH, PAFAH alpha, PAFAH1B1, PAFAHA, Platelet-activating factor acetylhydrolase IB subunit alpha, MDS
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLIS1
Short nameLIS1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLIS1 (Antibody to)
Alternative techniqueantibodies
Identity 8574
Gene PAFAH1B1
Long gene name platelet activating factor acetylhydrolase 1b regulatory subunit 1
Synonyms gene MDCR MDS
Synonyms gene name alpha subunit (45kD) Miller-Dieker syndrome chromosome region platelet-activating factor acetylhydrolase, alpha subunit 45kDa platelet-activating factor acetylhydrolase, isoform Ib, isoform Ib, isoform Ib, platelet-activating factor acetylhydrolase, regulatory subunit 1 (45kDa) , subunit 1 (45kDa) platelet-activating factor acetylhydrolase 1b
Synonyms LIS1 PAFAH NudF
Synonyms name lissencephaly-1
Locus 17p13, 3
Discovery year 1998-04-03
GenBank acession L25107
Entrez gene record 5048
Pubmed identfication 8355785 9063735
RefSeq identity NM_000430
Classification WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000177574

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