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SIM2 Antibody

SIM2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSIM2 Primary Polyclonal Antibody
Also known asSIM2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSIM2
SpecificityThis is a highly specific antibody against SIM2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIM2
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AhR, Arnt 1, Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, Several PAS domain family members have been identified including AhR, The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element, The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, The aromatic (aryl) hydrocarbon receptor, and single-minded proteins (SIM1 and SIM2), glutathione S-transferase Ya subunit and DT-diaphorase, is a candidate for the gene responsible for Down syndrome, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, thus inhibiting transcriptional activation, which is located on chromosome 21, The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Class E basic helix loop helix protein 15, Class E basic helix-loop-helix protein 15, MGC119447, SIM, SIM 2, SIM2_HUMAN, Sim2, Single minded homolog 2, Single minded homolog 2 Drosophila, Single-minded homolog 2, Transcription factor SIM2, bHLHe15
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSIM2
Short nameSIM2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSIM2 (Antibody to)
Alternative techniqueantibodies
Identity 10883
Gene SIM2
Long gene name single-minded family bHLH transcription factor 2
Synonyms gene SIM
Synonyms gene name single-minded (Drosophila) homolog 2 single-minded homolog 2 (Drosophila)
Synonyms MGC119447 bHLHe15
Synonyms name transcription factor SIM2
Locus 21q22, 13
Discovery year 1995-10-02
Entrez gene record 6493
Pubmed identfication 7485157
RefSeq identity NM_009586
Classification Basic helix-loop-helix proteins
Havana BLAST/BLAT OTTHUMG00000086637

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