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SLC26A6 Antibody

SLC26A6 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSLC26A6 Primary Polyclonal Antibody
Also known asSLC26A6 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSLC26A6
SpecificityThis is a highly specific antibody against SLC26A6
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range438-484/759
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLC26A6
Gene ID number65010
Swiss ProtQ9BXS9
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, Function in multiple exchange modes involving pairs of these anions, Isoform 4: Apical membrane chloride-bicarbonate exchanger, Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon, Mediates also intestinal chloride absorption and oxalate secretion, Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney, Plays a role in sperm capacitation by increasing intracellular pH, The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, Transepithelial oxalate secretion, and hence will dilute and alkalinize protein-rich acinar secretion, bicarbonate, chloride-formate, chloride-oxalate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner, formate and hydroxyl ion and divalent anions like sulfate and oxalate, hence maximizes the local concentration of bicarbonate at the transporter site, oxalate-formate, oxalate-sulfate and chloride-formate exchange, possibly by providing a bicarbonate import pathway, thereby preventing hyperoxaluria and calcium oxalate urolithiasis, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, which include chloride-bicarbonate, Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Anion exchange transporter, Pendrin-L1, Pendrin-like protein 1, SLC26A6, Solute carrier family 26 member 6
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSLC26A6
Short nameSLC26A6 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSLC26A6 (Antibody to)
Alternative techniqueantibodies
Identity 14472
Gene SLC26A6
Long gene name solute carrier family 26 member 6
Synonyms gene name member 6 , member 6 solute carrier family 26 (anion exchanger), solute carrier family 26
Synonyms DKFZp586E1422
Synonyms name pendrin-like protein 1 pendrin L1 sulfate anion transporter anion transporter 1
Locus 3p21, 31
Discovery year 2001-01-25
GenBank acession AF279265
Entrez gene record 65010
Pubmed identfication 11087667 11247665
RefSeq identity NM_022911
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000186381

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