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SLC5A3/SMIT Antibody

SLC5A3/SMIT Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameSLC5A3/SMIT Primary Polyclonal Antibody
Also known asSLC5A3/SMIT PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenSLC5A3/SMIT
SpecificityThis is a highly specific antibody against SLC5A3/SMIT
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLC5A3/SMIT
Tested Applications FCM, IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome, In kidney, It is expressed in many human tissues, It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT), SMIT activity maintains intracellular concentrations of myo-inositol, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD), Specifically, The human SMIT protein is encoded by the SLC5A3 gene, but is downregulated in adult rat brain with the exception of the choroid plexus, it is upregulated in response to hypertonic stress, kidney and placenta, signal transduction and osmoregulation, such as brain, where SMIT expression remains high, which maps to chromosome 21q22, 12, Myo-inositol is involved in many important aspects of cellular regulation including membrane structure
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Na+/myo-inositol cotransporter, SC5A3_HUMAN, SLC5A3, SMIT, SMIT2, Sodium/myo inositol cotransporter, Sodium/myo-inositol cotransporter, Solute carrier family 5 member 3, member 3, sodium/myo inositol cotransporter 1, solute carrier family 5 inositol transporters, Na+/myo inositol cotransporter
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetSLC5A3/SMIT
Short nameSLC5A3/SMIT Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameSLC5A3/SMIT (Antibody to)
Alternative techniqueantibodies
Identity 11038
Gene SLC5A3
Long gene name solute carrier family 5 member 3
Synonyms gene name member 3 , member 3 solute carrier family 5 (sodium/myo-inositol cotransporter), solute carrier family 5 (inositol transporter)
Synonyms SMIT SMIT1
Locus 21q22, 11
Discovery year 1994-02-15
Entrez gene record 6526
Pubmed identfication 7789985
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000065821

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