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TRF2 Antibody

TRF2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameTRF2 Primary Polyclonal Antibody
Also known asTRF2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenTRF2
SpecificityThis is a highly specific antibody against TRF2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range350-400/542
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRF2
Gene ID number7014
Swiss ProtQ15554
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, In addition to its telomeric DNA-binding role, Preferentially binds to positive supercoiled DNA, Recruits TERF2IP/RAP1 to telomeres, Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo, Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, TERF2IP/RAP1 and DCLRE1B/Apollo, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology, Together with DCLRE1B/Apollo, Together with DCLRE1B/Apollo, including the shelterin complex, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair, required to control the amount of DNA topoisomerase (TOP1, required to recruit a number of factors and enzymes required for telomere protection, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length, without its protective activity, Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names TERF2, TRBF2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, Telomeric repeat-binding factor 2, TRF2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetTRF2
Short nameTRF2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameTRF2 (Antibody to)
Alternative techniqueantibodies
Identity 11729
Gene TERF2
Long gene name telomeric repeat binding factor 2
Synonyms gene TRBF2
Synonyms TRF2
Locus 16q22, 1
Discovery year 1997-11-20
Entrez gene record 7014
Pubmed identfication 9326950 10226653
Classification Shelterin complex Myb/SANT domain containing
Havana BLAST/BLAT OTTHUMG00000137566

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