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lamin A/C Antibody

lamin A/C Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namelamin A/C Primary Polyclonal Antibody
Also known aslamin A/C PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenlamin A/C
SpecificityThis is a highly specific antibody against lamin A/C
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human lamin A
Gene ID number4000
Swiss ProtP02545
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also prevents fat infiltration of muscle and bone marrow, It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), Lamin A and C are present in equal amounts in the lamina of mammals, Plays an important role in nuclear assembly, Prelamin-A/C can accelerate smooth muscle cell senescence, Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation, Required for osteoblastogenesis and bone formation, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, and premature senescence, chromatin organization, genomic instability, helping to maintain the volume and strength of skeletal muscle and bone, leading to mitotic failure, nuclear membrane and telomere dynamics, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin, Lamins are components of the nuclear lamina
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, LMNL1, PRO1, Prelamin-A/C, FPL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetlamin A/C
Short namelamin A/C Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namelamin A/C (Antibody to)
Alternative techniqueantibodies
Identity 9450
Gene PRO1
Long gene name lamin A/C
Synonyms gene LMN1 CMD1A LGMD1B LMNL1
Synonyms gene name cardiomyopathy, dilated 1A (autosomal dominant) limb girdle muscular dystrophy 1B (autosomal dominant) progeria 1 (Hutchinson-Gilford type) lamin A/C-like 1
Synonyms HGPS MADA LMNA
Synonyms name mandibuloacral dysplasia type A
Locus 1q22
Discovery year 1992-04-09
GenBank acession BC014507
Entrez gene record 4000
Pubmed identfication 8511676 8838815 12702809
RefSeq identity NM_170707
Classification Lamins
Havana BLAST/BLAT OTTHUMG00000013961
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages LRG_254

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