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NEMO Antibody

NEMO Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNEMO Primary Polyclonal Antibody
Also known asNEMO PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNEMO
SpecificityThis is a highly specific antibody against NEMO
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range370-419/419
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NEMO
Gene ID number8517
Swiss ProtQ9Y6K9
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also considered to be a mediator for TAX activation of NF-kappa-B, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, However, Involved in TLR3- and IFIH1-mediated antiviral innate response, Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly, this function requires 'Lys-27'-linked polyubiquitination, Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AMCBX1, FIP-3, FIP3, Fip3p, I-kappa-B kinase subunit gamma, IKBKG, IKK-gamma, IKKAP1, IKKG, IMD33, IP1, IP2, IPD2, IkB kinase subunit gamma, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, NEMO, NF-kappa-B essential modifier, NF-kappa-B essential modulator, ZC2HC9, IP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNEMO
Short nameNEMO Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNEMO (Antibody to)
Alternative techniqueantibodies
Identity 5961
Gene IKBKG
Long gene name inhibitor of nuclear factor kappa B kinase subunit gamma
Synonyms gene IP2 IP1
Synonyms gene name incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Synonyms IKK-gamma NEMO Fip3p FIP-3 FIP3 ZC2HC9
Locus Xq28
Discovery year 1998-09-30
GenBank acession AF074382
Entrez gene record 8517
Pubmed identfication 9751060 10087442 11590134
RefSeq identity NM_003639
Classification Zinc fingers C2HC-type
Havana BLAST/BLAT OTTHUMG00000024234
Locus Specific Databases IKBKGbase: Mutation registry for Nemo deficiency Mental Retardation database LRG_70

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