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Rb Antibody

Rb Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenRb
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IF, WB, IHC
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Rb antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P06400
PurityAntigen affinity
Description It almost always presents in early childhood and is often bilateral, One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide, Retinoblastoma (Rb) is an embryonic malignant neoplasm of retinal origin, Should an oncogenic protein, bind and inactivate pRb, pRb belongs to the pocket protein family, such as those produced by cells infected by high-risk types of human papillomaviruses, this can lead to cancer, whose members have a pocket for the functional binding of other proteins, The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer
ImmunogenA portion of amino acids 586-615 from the human protein was used as the immunogen for this Rb antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Rb antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetRb
Short nameRb Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRb (Antibody to)
Alternative techniqueantibodies
Identity 9884
Gene RB1
Long gene name RB transcriptional corepressor 1
Synonyms gene OSRC
Synonyms gene name osteosarcoma retinoblastoma 1
Synonyms RB PPP1R130
Synonyms name prepro-retinoblastoma-associated protein protein phosphatase 1, regulatory subunit 130
Locus 13q14, 2
Discovery year 1986-01-01
GenBank acession M15400
Entrez gene record 5925
Pubmed identfication 1857421 15057823
RefSeq identity NM_000321
Classification Endogenous ligands
Havana BLAST/BLAT OTTHUMG00000016900
Locus Specific Databases RB1-LSDB LRG_517

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