| Specificity and cross-reactivity | Abundant granular eosinophilic cytoplasm is a common feature of renal oncocytoma, However, Immunostaining pattern with anti-mitochondrial MAb 113-1 has been reported as a useful discriminatory adjunct in the complex differential diagnosis of granular renal cell tumors, It can be used to stain mitochondria in cell or tissue preparations and can be used as a mitochondrial marker in subcellular fractions, It produces a spaghetti-like pattern in normal and malignant cells, It reacts specifically with human cells, Moreover, One study highlights the usefulness of 113-1 MAb to facilitate the classification of salivary tumors, Salivary gland tumors usually show great variability both in their morphopathology as well as their clinical behavior, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The chief reason for their distinction from one another is the difference in their biologic behavior, This antibody is an excellent marker for human cells in xenographic model research, This particular antibody might cross react with speacies outside of the listed ones, an aspect that may sometimes have not only diagnostic implications, and the granular variant of clear cell renal cell carcinoma (RCC), but also prognostic, chromophobe renal cell carcinoma, eosinophilic variant of papillary renal cell carcinoma, including neurons and embryonic stem cells, precise characterization may be difficult in some cases because of overlapping morphologic features, MAb 113-1 recognizes a 60kDa antigen associated with the mitochondria in human cells |