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RNF8 Antibody

RNF8 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRNF8 Primary Polyclonal Antibody
Also known asRNF8 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRNF8
SpecificityThis is a highly specific antibody against RNF8
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RNF8
Gene ID number9025
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen It increases RXR?mediated transactivation of the RXR?responsive element (RXRE) promoter in a dose-dependent manner, It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation, RNF8 also binds to Retinoid X receptor alpha (RXR?, RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase, RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains, The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, The ring finger protein (RNF) family includes any protein containing the signature RING finger motif, a member of the steroid hormone receptor superfamily, and they co-localize in the nucleus, suggesting that RNF8 is a regulator of RXR?mediated transcriptional activity, The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names E3 ubiquitin protein ligase RNF8, E3 ubiquitin-protein ligase RNF8, RING finger protein 8, RNF 8, RNF8, RNF8_HUMAN, Ring finger protein C3HC4 type 8, UBC13/UEV interacting ring finger protein, C3HC4 type zinc finger protein
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRNF8
Short nameRNF8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRNF8 (Antibody to)
Alternative techniqueantibodies
Identity 10071
Gene RNF8
Long gene name ring finger protein 8
Synonyms gene name E3 ubiquitin protein ligase , ring finger protein (C3HC4 type) 8 ring finger protein 8 ring finger protein 8
Synonyms KIAA0646
Locus 6p21, 2
Discovery year 1999-09-29
GenBank acession AB012770
Entrez gene record 9025
Pubmed identfication 9734811 9852682
Classification Ring finger proteins
Havana BLAST/BLAT OTTHUMG00000014620

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