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IDE Antibody

IDE Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIDE Primary Polyclonal Antibody
Also known asIDE PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIDE
SpecificityThis is a highly specific antibody against IDE
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IDE
Gene ID number3416
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin, Considered a zinc metalloproteinase, Generally thought to be a cytoplasmic protein, Human insulysin was cloned in 1988, IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin, In addition to the active metalloproteinase domain, Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates, Insulysin is a metalloproteinase of the clan ME, Insulysin is most closely related to the bacterial proteinase pitrilysin, Recent work implicates insulysin in clearing beta amyloid plaques from the brain, TGF alpha and amylin, The pH optimum for insulysin is basic, The sequence is well conserved between humans, a reversal of the canonical HExxH zinc binding motif, alpha amyloid protein, although the precise interactions between insulin and insulysin remain elusive, and can degrade intact insulin, and has generated much interest in Alzheimerâ, and is thought to assist in substrate binding, and perhaps also complexed with other molecules, and shown to be a 118 kDa protein that exists primarily as a homodimer, and the antibody recognizes these species, denatured hemoglobin, family M16, glucagon, insulin B chain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, insulysin has been isolated from many different tissues and cell lines, pH 8, rats and mice, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline, which also distinguishes it from other metalloproteinases, which contains an active site HxxEH, &euro, &trade, 5, Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, s disease research
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Abeta-degrading protease, FLJ35968, FLJ35968, IDE_HUMAN, Ide, Insulin degrading enzyme, Insulin-degrading enzyme, OTTHUMP00000020097, insulin protease, insulinase, insulysin, BC2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIDE
Short nameIDE Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameinsulin-degrading enzyme (Antibody to)
Alternative techniqueantibodies
Alternative to gene target IDE and IDBG-637578 and ENSBTAG00000019759 and 523752, IDE and IDBG-82456 and ENSG00000119912 and 3416, INSULYSIN, Ide and IDBG-161417 and ENSMUSG00000056999 and 15925, metal ion binding, nuclei, this GO :0001540 and beta-amyloid binding and molecular function this GO :0001948 and glycoprotein binding and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005782 and peroxisomal matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006508 and proteolysis and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008340 and determination of adult lifespan and biological process this GO :0009986 and cell surface and cellular component this GO :0010815 and bradykinin catabolic process and biological process this GO :0010992 and ubiquitin homeostasis and biological process this GO :0016032 and viral process and biological process this GO :0016887 and ATPase activity and molecular function this GO :0017046 and peptide hormone binding and molecular function this GO :0031597 and cytosolic proteasome complex and cellular component this GO :0031626 and beta-endorphin binding and molecular function this GO :0032461 and positive regulation of protein oli this GO merization and biological process this GO :0042277 and peptide binding and molecular function this GO :0042447 and hormone catabolic process and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043130 and ubiquitin binding and molecular function this GO :0043559 and insulin binding and molecular function this GO :0044257 and cellular protein catabolic process and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050435 and beta-amyloid metabolic process and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051289 and protein homotetramerization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :1901142 and insulin metabolic process and biological process this GO :1901143 and insulin catabolic process and biological process, this GO :0001540: beta-amyloid binding, this GO :0001540: beta-amyloid binding and also this GO :0001948: glycoprotein binding and also this GO :0003824: catalytic activity and also this GO :0004222: metalloendopeptidase activity and also this GO :0005102: receptor binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008270: zinc ion binding and also this GO :0016887: ATPase activity and also this GO :0017046: peptide hormone binding and also this GO :0031626: beta-endorphin binding and also this GO :0042277: peptide binding and also this GO :0042803: protein homodimerization activity and also this GO :0043130: ubiquitin binding and also this GO :0043559: insulin binding and also this GO :0046872: metal ion binding, this GO :0001948: glycoprotein binding, this GO :0003824: catalytic activity, this GO :0004222: metalloendopeptidase activity, this GO :0005102: receptor binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008270: zinc ion binding, this GO :0016887: ATPase activity, this GO :0017046: peptide hormone binding, this GO :0031626: beta-endorphin binding, this GO :0042277: peptide binding, this GO :0042803: protein homodimerization activity, this GO :0043130: ubiquitin binding, this GO :0043559: insulin binding, this GO :0046872: metal ion binding, insulin-degrading enzyme
Identity 5381
Gene IDE
Long gene name insulin degrading enzyme
Synonyms gene name insulin-degrading enzyme
Synonyms name insulysin
Locus 10q23, 33
Discovery year 1990-07-03
GenBank acession M21188
Entrez gene record 3416
Pubmed identfication 2293021
RefSeq identity NM_004969
Havana BLAST/BLAT OTTHUMG00000018759

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